The sum1-1 mutation affects silent mating-type gene transcription in Saccharomyces cerevisiae.

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Mating-type gene switching in Saccharomyces cerevisiae.

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A mutation allowing expression of normally silent a mating-type information in Saccharomyces cerevisiae.

Mating type in haploid cells of the yeast Saccharomyces cerevisiae is determined by a pair of alleles MATa and MAT alpha. Under various conditions haploid mating types can be interconverted. It has been proposed that transpositions of silent cassettes of mating-type information from HML OR HMR to MAT are the source of mating type conversions. A mutation described in this work, designated AON1, ...

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A mutation that permits the expression of normally silent copies of mating-type information in Saccharomyces cerevisiae.

Studies of heterothallic and homothallic strains of Saccharomyces cerevisiae have led to the suggestion that mating-type information is located at three distinct sites on chromosome 3, although only information at the mating-type (MAT) locus is expressed (Hicks, Strathern and Herskowitz, 1977). We have found that the recessive mutation cmt permits expression of the normally silent copies of mat...

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The silent mating-type loci HML and HMR of Saccharomyces cerevisiae contain mating-type information that is permanently repressed. This silencing is mediated by flanking sequence elements, the E- and I-silencers. They contain combinations of binding sites for the proteins Rap1, Abf1 and Sum1 as well as for the origin recognition complex (ORC). Together, they recruit other silencing factors, for...

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ژورنال

عنوان ژورنال: Molecular and Cellular Biology

سال: 1990

ISSN: 0270-7306,1098-5549

DOI: 10.1128/mcb.10.1.409